Alterations in intra- and inter-network connectivity associated with cognition impairment in insulinoma patients.

ABSTRACT:

Objective

Cognitive dysfunction is common in insulinoma patients, but the underlying neural mechanisms are less well understood. This study aimed to explore the alterations of intra- and inter-network connectivity patterns associated with patients with insulinoma.

Methods

Resting-state fMRI were acquired from 13 insulinoma patients and 13 matched healthy controls (HCs). Group Independent component analysis (ICA) was employed to capture the resting-state networks (RSNs), then the intra- and inter-network connectivity patterns, were calculated and compared. Montreal Cognitive Assessment (MoCA) was used to assess the cognitive function. The relationship between connectivity patterns and MoCA scores was also examined.

Results

Insulinoma patients performed significantly wo

SUBMITTER: Nong H 

PROVIDER: S-EPMC10561291 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature