The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity.

ABSTRACT: Proteins involved in cellular metabolism and molecular regulation can extend lifespan of various organisms in the laboratory. However, any improvement in aging would only provide an evolutionary benefit if the organisms were able to survive under non-ideal conditions. We have previously shown that Drosophila melanogaster carrying a loss-of-function allele of the acetyltransferase chameau (chm) has an increased healthy lifespan when fed ad libitum. Here, we show that loss of chm and reduction in its activity results in a substantial reduction in weight and a decrease in starvation resistance. This phenotype is caused by failure to properly regulate the genes and proteins required for energy storage and expenditure. The previously observed increase in survival time thus comes with the inabil

SUBMITTER: Venkatasubramani AV 

PROVIDER: S-EPMC10561354 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature