GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.

ABSTRACT:

Background

Obesity, characterized by excessive white adipose tissue expansion, is associated with several metabolic complications. Identifying new adipogenesis regulators may lead to effective therapies for obesity-induced metabolic disorders.

Results

Here, we identified the growth arrest and DNA damage-inducible A (GADD45A), a stress-inducible histone-folding protein, as a novel regulator of subcutaneous adipose metabolism. We found that GADD45A expression was positively correlated with subcutaneous fat deposition and obesity in humans and fatty animals. In vitro, the gain or loss function of GADD45A promoted or inhibited subcutaneous adipogenic differentiation and lipid accumulation, respectively. Using a Gadd45a^-/- mouse model, we showed that compared to wild-t

SUBMITTER: You W 

PROVIDER: S-EPMC10561432 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature