Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Growing evidence supports an association between physical activity (PA) and the risk of osteoarthritis (OA), but this may be influenced by confounding and reverse causality. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to reveal the causal relationship between PA and OA.

Methods

MR was performed to explore the causation of PA and OA with genetic variants as instrumental variables. The genetic variants were derived from the summary statistics of a large genome-wide association study meta-analysis based on the European population (n = 661,399), including self-reported leisure screen time (LST) and moderate-to-vigorous physical activity (MVPA), and Arthritis Research UK Osteoarthritis Genetics Consortium cohorts (417,596, 393,873 and 403

SUBMITTER: Wang B 

PROVIDER: S-EPMC10561455 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature