Safety and efficacy of biological agents in the treatment of Systemic Lupus Erythematosus (SLE).

ABSTRACT:

Background

To determine the safety and efficacy of biological agents used in the treatment of systemic lupus erythematosus (SLE) in adults.

Methods

Systematic review and meta-analysis following PRISMA guidelines.

Data sources

MEDLINE (through Pubmed), EMBASE, Cochrane library, Clinicaltrials.gov, Australianclinicaltrials.gov.au, ANZCTR.org.au and WHO International Clinical Trials Registry Platform for studies published from 20 May 2021 and 15 years prior. A grey literature search was performed and completed on 31 May 2021.

Study criteria

Phase II, III or quasi randomised controlled trials, studies with only cerebral or cutaneous lupus were excluded.

Data extraction

Two authors independently screened studies for eligibility, extracted, reviewed data for a

SUBMITTER: Chan J 

PROVIDER: S-EPMC10561476 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature