Systematic dissection of genomic features determining the vast diversity of conotoxins.

ABSTRACT:

Background

Conus, a highly diverse species of venomous predators, has attracted significant attention in neuroscience and new drug development due to their rich collection of neuroactive peptides called conotoxins. Recent advancements in transcriptome, proteome, and genome analyses have facilitated the identification of conotoxins within Conus' venom glands, providing insights into the genetic features and evolutionary patterns of conotoxin genes. However, the underlying mechanism behind the extraordinary hypervariability of conotoxins remains largely unknown.

Results

We analyzed the transcriptomes of 34 Conus species, examining various tissues such as the venom duct, venom bulb, and salivary gland, leading to the identification of conotoxin genes. Genetic variation analysis

SUBMITTER: Zheng JW 

PROVIDER: S-EPMC10561478 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature