The synthesis and characterization of a series of cocrystals of an isoniazid derivative with butan-2-one and propan-2-one.

ABSTRACT: Four cocrystals containing N'-(butan-2-ylidene)pyridine-4-carbohydrazide (izbt) and one cocrystal containing N'-isopropylideneisonicotinohydrazide (izact) were synthesized by reacting isoniazid with either butan-2-one (for the former) or acetone (for the latter). The coformers used to synthesize the izbt cocrystals were 2,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 2-chloro-4-nitrobenzoic acid and 1-naphthoic acid. 1-Naphthoic acid was also used with izact to form a cocrystal. The 1:1 cocrystals are: N'-(butan-2-ylidene)pyridine-4-carbohydrazide-1-naphthoic acid (izbt-1nta), C₁₀H₁₃N₃O·C₁₁H₈O₂, N'-(butan-2-ylidene)pyridine-4-carbohydrazide-2,4-dihydroxybenzoic acid (izbt-2,4-dhba), C₁₀H₁₃N_3<

SUBMITTER: Scheepers MC 

PROVIDER: S-EPMC10561595 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature