On the participation of adenosinergic receptors in the reconsolidation of spatial long-term memory in male rats.

ABSTRACT: To date, there is insufficient evidence to explain the role of adenosinergic receptors in the reconsolidation of long-term spatial memory. In this work, the role of the adenosinergic receptor family (A1, A2A, A2B, and A3) in this process has been elucidated. It was demonstrated that when infused bilaterally into the hippocampal CA1 region immediately after an early nonreinforced test session performed 24 h posttraining in the Morris water maze task, adenosine can cause anterograde amnesia for recent and late long-term spatial memory. This effect on spatial memory reconsolidation was blocked by A1 or A3 receptor antagonists and mimicked by A1 plus A3 receptor agonists, showing that this effect occurs through A1 and A3 receptors simultaneously. The A3 receptor alone participates only in the

SUBMITTER: Bosetto Fiebrantz AK 

PROVIDER: S-EPMC10561635 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature