Statin treatment is not associated with an increased risk of adrenal insufficiency in real-world setting.

ABSTRACT:

Introduction

Statins could reduce the synthesis of steroid hormones, thereby could cause adrenal insufficiency. We investigated this risk in a large nationwide database.

Methods

We conducted a nested case-control study using a cohort of individuals affiliated to the French health insurance system in 2010, ≥18y and without adrenal insufficiency history. Each case had a first event of adrenal insufficiency between 2015 and 2017 and was matched to up to ten controls on age, sex, and prior treatment with corticosteroids. Statin exposure was measured over the five years preceding the index date, considering a six-month censoring lag-time. Association was estimated using a conditional logistic regression adjusted for confounders included in a disease risk score. Analyses were stra

SUBMITTER: Maumus-Robert S 

PROVIDER: S-EPMC10561645 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature