Efficacy and Safety of Low-dose Oral Prednisolone for Patients with Refractory Hunner-type Interstitial Cystitis.

ABSTRACT:

Background

Hunner-type interstitial cystitis (HIC) is an immunological, chronic inflammatory disease. The efficacy of corticosteroid as a treatment for HIC is unclear.

Objective

To assess the efficacy and safety of low-dose oral prednisolone (PSL) treatment for patients with refractory HIC.

Design setting and participants

This retrospective observational study reviewed the clinical outcomes of 31 patients with refractory HIC who received oral PSL daily (initial dose, 5.0 or 7.5 mg) for at least 12 mo between 2016 and 2023. The dose was tapered to the minimum that maintained symptom relief during follow-up.

Outcome measurements and statistical analysis

Treatment outcomes were evaluated using a seven-graded global response assessment (scores ≥+2, moderately or ma

SUBMITTER: Akiyama Y 

PROVIDER: S-EPMC10562155 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature