Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis.

ABSTRACT: Exosomes (Exos) secreted by adipose-derived stem cells (ADSCs) have shown potential in alleviating osteoarthritis (OA). Previous studies indicated that infrapatellar fat pad (IPFP) derived stem cells (IPFSCs) may be more suitable for the treatment of OA than subcutaneous adipose tissue (ScAT) derived stem cells (ScASCs). However, it remains unclear which type of Exos offers superior therapeutic benefit for OA. This study first compared the differences between Exos derived from IPFP stem cells (Exos^IPFP) and ScAT stem cells (Exos^ScAT) in OA treatment. Results suggested that Exos^IPFP significantly inhibit the degradation of cartilage extracellular matrix (ECM) than Exos^ScAT, following this, the differences in microRNA (miRNA) expression between the

SUBMITTER: Yin Z 

PROVIDER: S-EPMC10562164 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature