Allogeneic tumor cell-derived extracellular vesicles stimulate CD8 T cell response in colorectal cancer.

ABSTRACT: Most colorectal cancer (CRC) patients present with a microsatellite-stable phenotype, rendering them resistant to immune checkpoint inhibitors (ICIs). Among the contributors to ICI resistance, tumor-derived extracellular vesicles (TEVs) have emerged as critical players. Previously we demonstrated that autologous transfer of TEVs without miR-424 can induce tumor antigen-specific immune responses in CRC models. Therefore, we postulated that allogeneic TEVs, modified to lack miR-424 and derived from an MC38 cells, could induce CD8⁺ T cell responses while restraining CT26 cell-based tumor. Here, we show that prophylactic administration of MC38 TEVs, without miR-424, showed a significant augmentation in CD8⁺ T-cells within CT26 tumors. This allogenic TEV effect was evident

SUBMITTER: Gates TJ 

PROVIDER: S-EPMC10562189 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature