Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae.

ABSTRACT:

Purpose

Olfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on quality of life, physical and mental health.

Methods

OD prevalence was assessed in an ambulatory COVID-19 survey (n = 906, ≥ 90 days follow-up) and an observational cohort of ambulatory and hospitalized individuals (n = 108, 360 days follow-up). Co-occurrence of OD with other symptoms and effects on quality of life, physical and mental health were analyzed by multi-dimensional scaling, association rule mining and semi-supervised clustering.

Results

Both in the ambulatory COVID-19 survey study (72%) and the observational ambulatory and hospitalized cohort

SUBMITTER: Rass V 

PROVIDER: S-EPMC10562286 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature