Asymmetric formal sp²-hydrocarbonations of dienes and alkynes via palladium hydride catalysis.

ABSTRACT: Transition metal-catalyzed asymmetric hydrofunctionalizations of unsaturated bonds via π-ƞ³ substitution have emerged as a reliable method to construct stereogenic centers, and mainly rely on the use of heteroatom-based or carbon nucleophiles bearing acidic C-H bonds. In comparison, sp² carbon nucleophiles are generally not under consideration because of enormous challenges in cleaving corresponding inert sp² C-H bonds. Here, we report a protocol to achieve asymmetric formal sp² hydrocarbonations, including hydroalkenylation, hydroallenylation and hydroketenimination of both 1,3-dienes and alkynes via hydroalkylation and Wittig reaction cascade. A series of unachievable motifs via hydrofunctionalizations, such as di-, tri- and tetra-substituted a

SUBMITTER: Tang MQ 

PROVIDER: S-EPMC10562392 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature