Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release.

ABSTRACT: Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During stimulation, microglia undergo complex morphological changes, including loss of their characteristic ramified morphology, which is routinely used to detect and quantify inflammation in the brain. However, the underlying molecular mechanisms and the relation between microglial morphology and their pathophysiological function are unknown. Here, proteomic profiling of lipopolysaccharide (LPS)-reactive microglia identifies microtubule remodeling pathways as an early factor that drives the morphological change and subsequently controls cytokine responses. We find that LPS-reactive microglia reorganize their microtubules to form a stable and centrosomally-anchored array to facilitate efficient cytokine tr

SUBMITTER: Adrian M 

PROVIDER: S-EPMC10562429 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature