The amniotic fluid proteome changes across gestation in humans and rhesus macaques.

ABSTRACT: Amniotic fluid is a complex biological medium that offers protection to the fetus and plays a key role in normal fetal nutrition, organogenesis, and potentially fetal programming. Amniotic fluid is also critically involved in longitudinally shaping the in utero milieu during pregnancy. Yet, the molecular mechanism(s) of action by which amniotic fluid regulates fetal development is ill-defined partly due to an incomplete understanding of the evolving composition of the amniotic fluid proteome. Prior research consisting of cross-sectional studies suggests that the amniotic fluid proteome changes as pregnancy advances, yet longitudinal alterations have not been confirmed because repeated sampling is prohibitive in humans. We therefore performed serial amniocenteses at early, mid, and late ges

SUBMITTER: Shorey-Kendrick LE 

PROVIDER: S-EPMC10562452 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature