Ontology highlight
ABSTRACT:
SUBMITTER: Dalla E
PROVIDER: S-EPMC10562521 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Dalla Erica E Sreekumar Amulya A Aguirre-Ghiso Julio A JA Chodosh Lewis A LA
Cold Spring Harbor perspectives in medicine 20231101 11
The pattern of delayed recurrence in a subset of breast cancer patients has long been explained by a model that incorporates a variable period of cellular or tumor mass dormancy prior to disease relapse. In this review, we critically evaluate existing data to develop a framework for inferring the existence of dormancy in clinical contexts of breast cancer. We integrate these clinical data with rapidly evolving mechanistic insights into breast cancer dormancy derived from a broad array of genetic ...[more]