Comparative computational analysis to distinguish mesenchymal stem cells from fibroblasts.

ABSTRACT:

Introduction

Mesenchymal stem cells (MSCs) are considered to be the most promising stem cell type for cell-based therapies in regenerative medicine. Based on their potential to home to diseased body sites following a therapeutically application, these cells could (i) differentiate then into organ-specific cell types to locally restore injured cells or, most prominently, (ii) foster tissue regeneration including immune modulations more indirectly by secretion of protective growth factors and cytokines. As tissue-resident stem cells of mesenchymal origin, these cells are morphologically and even molecularly- at least concerning the classical marker genes- indistinguishable from similar lineage cells, particularly fibroblasts.

Methods

Here we used microarray-based gene expressi

SUBMITTER: Budeus B 

PROVIDER: S-EPMC10562561 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature