Engineered exosomes as drug and RNA co-delivery system: new hope for enhanced therapeutics?

ABSTRACT: Chemotherapy often faces some obstacles such as low targeting effects and drug resistance, which introduce the low therapeutic efficiency and strong side effects. Recent advances in nanotechnology allows the use of novel nanosystems for targeted drug delivery, although the chemically synthesized nanomaterials always show unexpected low biocompability. The emergence of exosome research has offered a better understanding of disease treatment and created novel opportunities for developing effective drug delivery systems with high biocompability. Moreover, RNA interference has emerged as a promising strategy for disease treatments by selectively knocking down or over-expressing specific genes, which allows new possibilities to directly control cell signaling events or drug resistance. Recently

SUBMITTER: Chen H 

PROVIDER: S-EPMC10562639 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature