Persistence is key: unresolved immune dysfunction is lethal in both COVID-19 and non-COVID-19 sepsis.

ABSTRACT:

Introduction

Severe COVID-19 and non-COVID-19 pulmonary sepsis share pathophysiological, immunological, and clinical features, suggesting that severe COVID-19 is a form of viral sepsis. Our objective was to identify shared gene expression trajectories strongly associated with eventual mortality between severe COVID-19 patients and contemporaneous non-COVID-19 sepsis patients in the intensive care unit (ICU) for potential therapeutic implications.

Methods

Whole blood was drawn from 20 COVID-19 patients and 22 non-COVID-19 adult sepsis patients at two timepoints: ICU admission and approximately a week later. RNA-Seq was performed on whole blood to identify differentially expressed genes and significantly enriched pathways. Using systems biology methods, drug candidates targeti

SUBMITTER: An AY 

PROVIDER: S-EPMC10562687 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature