Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis.

ABSTRACT:

Introduction

Among immune cells, activated monocytes play a detrimental role in chronic and viral-induced inflammatory pathologies, particularly in Juvenile Idiopathic Arthritis (JIA), a childhood rheumatoid arthritis (RA) disease. The uncontrolled activation of monocytes and excessive production of inflammatory factors contribute to the damage of bone-cartilage joints. Despite the moderate beneficial effect of current therapies and clinical trials, there is still a need for alternative strategies targeting monocytes to treat RA.

Methods

To explore such an alternative strategy, we investigated the effects of targeting the CXCR4 receptor using the histamine analog clobenpropit (CB). Monocytes were isolated from the blood and synovial fluids of JIA patients to assess CB's impa

SUBMITTER: Bekaddour N 

PROVIDER: S-EPMC10562697 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature