Translation factor and RNA binding protein mRNA interactomes support broader RNA regulons for posttranscriptional control.

ABSTRACT: The regulation of translation provides a rapid and direct mechanism to modulate the cellular proteome. In eukaryotes, an established model for the recruitment of ribosomes to mRNA depends upon a set of conserved translation initiation factors. Nevertheless, how cells orchestrate and define the selection of individual mRNAs for translation, as opposed to other potential cytosolic fates, is poorly understood. We have previously found significant variation in the interaction between individual mRNAs and an array of translation initiation factors. Indeed, mRNAs can be separated into different classes based upon these interactions to provide a framework for understanding different modes of translation initiation. Here, we extend this approach to include new mRNA interaction profiles for additio

SUBMITTER: Kershaw CJ 

PROVIDER: S-EPMC10562868 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature