Associations of 24-Hour Light Exposure and Activity Patterns and Risk of Cognitive Impairment and Decline in Older Men: The MrOS Sleep Study.

ABSTRACT:

Background

Older men with the worse alignment of activity and light may have lower levels of cognition and increased rates of cognitive decline.

Methods

This cohort consisted of 1 036 older men (81.1 ± 4.6 years) from the MrOS Sleep Study (2009-2012). Light and activity levels were gathered by wrist actigraphy. Phasor analysis was used to quantify the alignment of light-dark and rest-activity patterns (magnitude) and their temporal relationship (angle). Global cognitive function (Modified Mini-Mental State examination [3MS]) and executive function (Trails B test) were measured, then repeated 4.2 ± 0.8 years later. Linear regression models examined the associations of phasor magnitude and angle with cognition and cognitive decline. Models were adjusted for age, clinic, race,

SUBMITTER: Blackwell TL 

PROVIDER: S-EPMC10562886 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature