Associations of essential trace elements with epigenetic aging indicators and the potential mediating role of inflammation.

ABSTRACT:

Background

Essential trace elements (ETEs) play essential roles in vital functions, but their effects on epigenetic aging remain poorly understood.

Objectives

This study aimed to investigate the associations of ETEs with four epigenetic aging indicators and assess the potential mediating role of inflammation.

Methods

We recruited 93 individuals from hospitals between October 2018 and August 2019. Plasma levels of cobalt, copper, iron, manganese, molybdenum, selenium, and zinc were measured by ICP-MS, and leukocyte DNA methylation levels were measured using Illumina MethylationEPIC beadchip. Linear regression was used to estimate the association between seven plasma ETEs and epigenetic aging indicators. Weighted quantile sum (WQS) regression and Bayesian kernel machine

SUBMITTER: Cheng X 

PROVIDER: S-EPMC10562911 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature