Circulating neutrophil anti-pathogen dysfunction in cirrhosis.

ABSTRACT: Neutrophils are the largest population of leucocytes and are among the first cells of the innate immune system to fight against intruding pathogens. In patients with cirrhosis, neutrophils exhibit altered functionality, including changes in phagocytic ability, bacterial killing, chemotaxis, degranulation, reactive oxygen species production and NET (neutrophil extracellular trap) formation. This results in their inability to mount an adequate antibacterial response and protect the individual from infection. Prognosis and survival in patients with cirrhosis are greatly influenced by the development of infectious complications. Multidrug-resistant bacterial infections in patients with cirrhosis are currently a growing problem worldwide; therefore, alternative methods for the prevention and tr

SUBMITTER: Balazs I 

PROVIDER: S-EPMC10562928 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature