Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease.

ABSTRACT:

Importance

Factors associated with synapse loss beyond amyloid-β plaques and neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in Alzheimer disease (AD) and be relevant for early therapeutic intervention.

Objective

To investigate whether accumulation of tau oligomers in synapses is associated with excessive synapse elimination by microglia or astrocytes and with cognitive outcomes (dementia vs no dementia [hereinafter termed resilient]) of individuals with equal burdens of AD neuropathologic changes at autopsy.

Design, setting, and participants

This cross-sectional postmortem study included 40 human brains from the Massachusetts Alzheimer Disease Research Center Brain Bank with Braak III to IV stages of tau pathology but diver

SUBMITTER: Taddei RN 

PROVIDER: S-EPMC10562992 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature