Exosomes released from PD-L1⁺ tumor associated macrophages promote peritoneal metastasis of epithelial ovarian cancer by up-regulating T cell lipid metabolism.

ABSTRACT: Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneum, and the prognosis of patients is poor. In the peritoneum of patients with EOC, TAMs (tumor associated macrophages) regulate the imbalance of T cell ratio and promote the progression and metastasis of EOC. However, the mechanism of peritoneal metastasis in EOC patients remains unclear. Here, we confirmed that the percentages of PD-L1⁺ TAMs in EOC tissues increased significantly, and TAMs-derived PD-L1⁺ exosomes affected the transcription factor PPARα to up-regulate the expression of CPT1A in CD8⁺ T cells, promote fatty acid oxidation, and increase reactive oxygen species to cause cell damage. The apoptosis of CD8⁺ T cells was increased, and the expressions of their exhaustion

SUBMITTER: Ma J 

PROVIDER: S-EPMC10563010 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature