Supramolecular self-assembly of EGCG-selenomethionine nanodrug for treating osteoarthritis.

ABSTRACT: Osteoarthritis (OA) has emerged as a significant health concern among the elderly population, with increasing attention paid to ferroptosis-induced OA in recent years. However, the prolonged use of nonsteroidal anti-inflammatory drugs or corticosteroids can lead to a series of side effects and limited therapeutic efficacy. This study aimed to employ the Mannich condensation reaction between epigallocatechin-3-gallate (EGCG) and selenomethionine (SeMet) to efficiently synthesize polyphenol-based nanodrugs in aqueous media for treating OA. Molecular biology experiments demonstrated that EGCG-based nanodrugs (ES NDs) could effectively reduce glutathione peroxidase 4 (GPX4) inactivation, abnormal Fe²⁺ accumulation, and lipid peroxidation induced by oxidative stress, which ameliorate

SUBMITTER: Yu H 

PROVIDER: S-EPMC10563013 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature