Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives.

ABSTRACT:

Background

Cardiovascular screening is recommended for first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for DCM patients without known familial DCM, for non-White FDRs, or for DCM partial phenotypes of left ventricular enlargement (LVE) or left ventricular systolic dysfunction (LVSD).

Objectives

This study examined the yield of clinical screening among reportedly unaffected FDRs of DCM patients.

Methods

Adult FDRs of DCM patients at 25 sites completed screening echocardiograms and ECGs. Mixed models accounting for site heterogeneity and intrafamilial correlation were used to compare screen-based percentages of DCM, LVSD, or LVE by FDR demographics, cardiovascular risk factors, and proband genetics

SUBMITTER: Ni H 

PROVIDER: S-EPMC10563038 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature