Phables: from fragmented assemblies to high-quality bacteriophage genomes.

ABSTRACT:

Motivation

Microbial communities have a profound impact on both human health and various environments. Viruses infecting bacteria, known as bacteriophages or phages, play a key role in modulating bacterial communities within environments. High-quality phage genome sequences are essential for advancing our understanding of phage biology, enabling comparative genomics studies and developing phage-based diagnostic tools. Most available viral identification tools consider individual sequences to determine whether they are of viral origin. As a result of challenges in viral assembly, fragmentation of genomes can occur, and existing tools may recover incomplete genome fragments. Therefore, the identification and characterization of novel phage genomes remain a challenge, leading to the n

SUBMITTER: Mallawaarachchi V 

PROVIDER: S-EPMC10563150 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature