The Potential Targets and Mechanisms of a Carbazole and Pyrazole Containing Anticancer Compound.

ABSTRACT:

Aims

Characterization of a small anticancer compound.

Background

The development of small molecules as new anti-cancer therapeutics is necessary to improve anti-tumor efficacy and reduce toxicities, especially for the treatment of brain tumors, where only small molecules can effectively cross the brain-blood barrier. Several novel hits were previously selected by concurrently screening colon and glioma cancer cell lines with a sensorconjugated reporter system. Here, we focused on one of them.

Objective

Elucidating the potential target(s) of a novel anticancer compound.

Methods

Computer-assisted structural and motif analysis (least absolute shrinkage and selection operator or LASSO score) was used to assess compound's targets, then direct kinase activity assays

SUBMITTER: Xie J 

PROVIDER: S-EPMC10563180 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature