Methylene Blue for Refractory Shock in Children: A Systematic Review and Survey Practice Analysis.

ABSTRACT:

Objectives

Shock refractory to fluid and catecholamine therapy has significant morbidity and mortality in children. The use of methylene blue to treat refractory shock in children is not well described. We aim to collect and summarize the literature and define physicians' practice patterns regarding the use of methylene blue to treat shock in children.

Design

We conducted a systematic search of MEDLINE, Embase, PubMed, Web of Science, Cochrane for studies involving the use of methylene blue for catecholamine-refractory shock from database inception to 2019. Collected studies were analyzed qualitatively. To describe practice patterns of methylene blue use, we electronically distributed a survey to U.S.-based pediatric critical care physicians. We assessed physician knowledge

SUBMITTER: Otero Luna AV 

PROVIDER: S-EPMC10563197 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature