Low levels of small HDL particles predict but do not influence risk of sepsis.

ABSTRACT:

Background

Low levels of high-density lipoprotein (HDL) cholesterol have been associated with higher rates and severity of infection. Alterations in inflammatory mediators and infection are associated with alterations in HDL cholesterol. It is unknown whether the association between HDL and infection is present for all particle sizes, and whether the observed associations are confounded by IL-6 signalling.

Methods

In the UK Biobank, ~ 270,000 individuals have data on HDL subclasses derived from nuclear magnetic resonance analysis. We estimated the association of particle count of total HDL and HDL subclasses (small, medium, large, and extra-large HDL) with sepsis, sepsis-related death, and critical care admission in a Cox regression model. We subsequently utilised genetic da

SUBMITTER: Hamilton F 

PROVIDER: S-EPMC10563213 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature