Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells.

ABSTRACT:

Background

Peste des petits ruminants virus (PPRV) is a highly contagious pathogen that strongly influences the productivity of small ruminants worldwide. Acetylation is an important post-translational modification involved in regulation of multiple biological functions. However, the extent and function of acetylation in host cells during PPRV infection remains unknown.

Methods

Dimethylation-labeling-based quantitative proteomic analysis of the acetylome of PPRV-infected Vero cells was performed.

Results

In total, 1068 proteins with 2641 modification sites were detected in response to PPRV infection, of which 304 differentially acetylated proteins (DAcPs) with 410 acetylated sites were identified (fold change < 0.83 or > 1.2 and P < 0.05), including 109 up-regulated a

SUBMITTER: Meng X 

PROVIDER: S-EPMC10563215 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature