New statistical selection method for pleiotropic variants associated with both quantitative and qualitative traits.

ABSTRACT:

Background

Identification of pleiotropic variants associated with multiple phenotypic traits has received increasing attention in genetic association studies. Overlapping genetic associations from multiple traits help to detect weak genetic associations missed by single-trait analyses. Many statistical methods were developed to identify pleiotropic variants with most of them being limited to quantitative traits when pleiotropic effects on both quantitative and qualitative traits have been observed. This is a statistically challenging problem because there does not exist an appropriate multivariate distribution to model both quantitative and qualitative data together. Alternatively, meta-analysis methods can be applied, which basically integrate summary statistics of individual vari

SUBMITTER: Kim K 

PROVIDER: S-EPMC10563219 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature