The mechanism of oleic acid inhibiting platelet activation stimulated by collagen.

ABSTRACT:

Background

Abnormal platelet activation is a key factor in the occurrence and development of thrombotic diseases. However, the physiological mechanisms that underlie platelet homeostasis remain unclear. Oleic acid, one of the most abundant lipids in the human diet, has potential antithrombotic effects. This study aimed to investigate the effects of oleic acid on platelet activation and thrombosis.

Methods

Platelet aggregation, ATP release, and fibrinogen spread were evaluated to determine the role of oleic acid in platelet activation. A ferric chloride-induced carotid injury model was used to establish the effect of oleic acid on thrombus formation in vivo. Western blotting analysis and transfection experiments were performed to determine the mechanisms involved in this proc

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10563249 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature