MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor.

ABSTRACT:

Background

The Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcription factor. Previous studies have identified elevated expression of MAPK1 in human gastric cancer, which is associated with its role as a kinase, facilitating the migration and invasion of gastric cancer cells. However, how MAPK1 binds to its target genes as a transcription factor and whether it modulates related gene expressions in gastric cancer remains unclear.

Results

Here, we integrated biochemical assays (protein interactions and chromatin immunoprecipitation (ChIP)), cellular analysis assays (cell proliferation and migration), RNA sequencing, ChIP s

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10563293 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature