Concentric-mineralized hybrid silk-based scaffolds for bone tissue engineering in vitro models.

ABSTRACT: There are many challenges in the development of 3D-tissue models for studying bone physiology and disease. Silk fibroin (SF), a natural fibrous protein used in biomedical applications has been studied for bone tissue engineering (TE) due to its mechanical properties, biocompatibility and biodegradability. However, low osteogenic capacity as well as the necessity to reinforce the protein mechanically for some orthopedic applications prompts the need for further designs for SF-based materials for TE bone. Concentric mineralized porous SF-based scaffolds were developed to improve mechanics and mineralization towards osteoregeneration. Hybrid SF silica microparticles (MP) or calcium carbonate nano-structured microparticles (NMP) were seeded with hMSCs co-cultured under osteogenic and osteoclas

SUBMITTER: Bosio VE 

PROVIDER: S-EPMC10563295 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature