Improvement of composite kidney outcomes by AKI care bundles: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Various approaches have been suggested to identify acute kidney injury (AKI) early and to initiate kidney-protective measures in patients at risk or with AKI. The objective of this study was to evaluate whether care bundles improve kidney outcomes in these patients.

Methods

We conducted a systematic review of the literature to evaluate the clinical effectiveness of AKI care bundles with or without urinary biomarkers in the recognition and management of AKI. The main outcomes were major adverse kidney events (MAKEs) consisting of moderate-severe AKI, receipt of renal replacement therapy (RRT), and mortality.

Results

Out of 7434 abstracts screened, 946 published studies were identified. Thirteen studies [five randomized controlled trials (RCTs) and eight no

SUBMITTER: See CY 

PROVIDER: S-EPMC10563300 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature