CD22 is a potential target of CAR-NK cell therapy for esophageal squamous cell carcinoma.

ABSTRACT:

Background

Chimeric antigen receptor NK (CAR-NK) cell therapy is one of the most promising immunotherapies. Although it has shown a significant therapeutic effect in hematologic malignancies, few successes have been obtained in solid tumors including esophageal squamous cell carcinoma (ESCC). The major reasons are lack of specific cell surface antigens and complex tumor microenvironment. Here we identify CD22, a well-known tumor surface marker in hematologic malignancies, is expressed in ESCC, possibly serving as a potential target of CAR-NK cell therapy.

Methods

The expression of 13 tumor cell surface antigens used clinically was analyzed in patients from The Cancer Genome Atlas (TCGA) database. Also, mRNA expression were detected in 2 ESCC cell lines and 2 patients samples

SUBMITTER: Liu T 

PROVIDER: S-EPMC10563326 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature