Single-cell RNA sequencing reveals a peripheral landscape of immune cells in Schistosomiasis japonica.

ABSTRACT:

Background

Schistosomiasis, also known as bilharzia, is a devastating parasitic disease. This progressive and debilitating helminth disease is often associated with poverty and can lead to chronic poor health. Despite ongoing research, there is currently no effective vaccine for schistosomiasis, and praziquantel remains the only available treatment option. According to the progression of schistosomiasis, infections caused by schistosomes are classified into three distinct clinical phases: acute, chronic and advanced schistosomiasis. However, the underlying immune mechanism involved in the progression of schistosomiasis remains poorly understood.

Methods

We employed single-cell RNA sequencing (scRNA-seq) to profile the immune landscape of Schistosomiasis japonica infection ba

SUBMITTER: Li J 

PROVIDER: S-EPMC10563327 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature