Association between subclinical atherosclerosis and cardiac structure and function-results from the UK Biobank Study.

ABSTRACT:

Aims

Heart failure (HF) is a major health problem and early diagnosis is important. Atherosclerosis is the main cause of HF and carotid intima-media thickness (IMT) is a recognized early measure of atherosclerosis. This study aimed to investigate whether increased carotid IMT is associated with changes in cardiac structure and function in middle-aged participants of the UK Biobank Study without overt cardiovascular disease.

Methods and results

Participants of the UK Biobank who underwent CMR and carotid ultrasound examinations were included in this study. Patients with heart failure, angina, atrial fibrillation, and history of myocardial infarction or stroke were excluded. We used multivariable linear regression models adjusted for age, sex, physical activity, body mass inde

SUBMITTER: Simon J 

PROVIDER: S-EPMC10563379 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature