A Lower Dose of Infection Generates a Better Long-Term Immune Response against Toxoplasma gondii.

ABSTRACT: Toxoplasma gondii, an obligate intracellular pathogen, induces a strong immune response in the infected host. In the encephalitis model of infection, long-term protective immunity is mediated by CD8 T cells, with the CD4 T cell population providing important help. Most of the immune studies have used a 10- to 20-cyst dose of T. gondii, which leads to T cell dysfunctionality during the late phase of chronic infection and increases the chances of reactivation. In the current study, we compared the immune response of mice orally infected with either 2 or 10 cysts of T. gondii. During the acute phase, we demonstrate that the lower dose of infection generates a reduced number of CD4 and CD8 T cells, but the frequency of functional CD4 or CD8 T cells is similar in animals infected with two diffe

SUBMITTER: Moretto MM 

PROVIDER: S-EPMC10563383 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature