FAM210B Regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis.

ABSTRACT: Iron is required for redox homeostasis but poses toxicity risks due to its redox activity. Erythropoiesis hence requires tight regulation of iron utilization for hemoglobin synthesis. The requirement for iron in erythropoiesis has necessitated the evolution of mechanisms to handle the iron required for hemoglobinization. FAM210B was identified as a regulator of mitochondrial iron import and heme synthesis in erythroid cell culture and zebrafish models. Here, we demonstrate that while FAM210B is required for erythroid differentiation and heme synthesis under standard cell culture conditions, holotransferrin supplementation was sufficient to chemically complement the iron-deficient phenotype. To investigate the role of FAM210B in erythropoiesis, we used knockout mice. While Fam210b

SUBMITTER: Perfetto M 

PROVIDER: S-EPMC10563458 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature