Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.

ABSTRACT:

Introduction

Altered immune signatures are emerging as a central theme in neurodegenerative disease, yet little is known about immune responses in early-onset Alzheimer's disease (EOAD).

Methods

We examined single-cell RNA-sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) and droplet digital (dd)PCR data from CD4 T cells from participants with EOAD and clinically normal controls.

Results

We analyzed ~182,000 PBMCs by scRNA-seq and discovered increased interferon signaling-associated gene (ISAG) expression and striking expansion of antiviral-like ISAG^hi T cells in EOAD. We isolated CD4 T cells from additional EOAD cases and confirmed increased expression of ISAG^hi marker genes. Publicly available cerebrospinal fluid leuko

SUBMITTER: Sirkis DW 

PROVIDER: S-EPMC10563505 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature