Peptides disrupting TM4SF3 interaction with AR or AR-V7 block prostate cancer cell proliferation.

ABSTRACT: Androgen receptor (AR) plays a vital role in the development and progression of prostate cancer from the primary stage to the usually lethal stage known as castration-resistant prostate cancer (CRPC). Constitutively active AR splice variants (AR-Vs) lacking the ligand-binding domain are partially responsible for the abnormal activation of AR and may be involved in resistance to AR-targeting drugs occurring in CRPC. There is increasing consensus on the potential of drugs targeting protein-protein interactions. Our lab has recently identified transmembrane 4 superfamily 3 (TM4SF3) as a critical interacting partner for AR and AR-V7 and mapped the minimal interaction regions. Thus, we hypothesized that these interaction domains can be used to design peptides that can disrupt the AR/TM4SF3 inte

SUBMITTER: Khatiwada P 

PROVIDER: S-EPMC10563598 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature