Metyrosine-associated endocrinological changes in pheochromocytoma and paraganglioma.

ABSTRACT:

Objective

Metyrosine (alpha-methyl-para-tyrosine) effectively reduces catecholamine levels in patients with pheochromocytoma/paraganglioma. However, improvements in physiological and metabolic parameters and changes in endocrine function associated with metyrosine administration should be validated in comparison to surgery. This study was performed to confirm the effects of metyrosine on the physiological, metabolic, and endocrinological functions of patients with pheochromocytoma/paraganglioma in the perioperative period.

Design

This retrospective cohort study was performed at a single university hospital.

Methods

We included ten patients with pheochromocytoma/paraganglioma who received oral metyrosine after α-blocker therapy and consecutive surgeries. Urinary catech

SUBMITTER: Matsuo Y 

PROVIDER: S-EPMC10563611 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature