3'sialyllactose and 6'sialyllactose enhance performance in endurance-type exercise through metabolic adaptation.

ABSTRACT: Human milk oligosaccharides (HMOs) belong to a group of multifunctional glycans that are abundantly present in human breast milk. While health effects of neutral oligosaccharides have been investigated extensively, a lot remains unknown regarding health effects of acidic oligosaccharides, such as the two sialyllactoses (SLs), 3'sialyllactose (3'SL), and 6'sialyllactose (6'SL). We utilized Caenorhabditis elegans (C. elegans) to investigate the effects of SLs on exercise performance. Using swimming as an endurance-type exercise, we found that SLs decrease exhaustion, signifying an increase in endurance that is strongest for 6'SL. Through an unbiased metabolomics approach, we identified changes in energy metabolism that correlated with endurance performance. Further investigatio

SUBMITTER: Arellano Spadaro J 

PROVIDER: S-EPMC10563706 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature