Preclinical study of pachyman inducing ferroptosis against ovarian cancer: Biological targets and underlying mechanisms.

ABSTRACT: Ferroptosis has gained extreme purpose in targeting cancer treatment. Poria cocos Wolf, a traditional Chinese herb, has potential anticancer properties, but the action and mechanism against ovarian cancer remain undetailed. Pachyman (Poria cocos polysaccharides) refers to the pharmacologically bioactive ingredients rich in Poria cocos. This study aimed to identify the potent actions and the network mechanisms of pachyman against ovarian cancer through preclinical analysis. Online-accessible database or platform was employed to predict candidate genes and core targets associated with ferroptosis in pachyman against ovarian cancer. Enrichment analyses were used to characterize the functional action and signaling mechanism in pachyman to treat ovarian cancer. Molecular do

SUBMITTER: Li B 

PROVIDER: S-EPMC10563710 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature