The effects of unsaturated fatty acids on psoriasis: A two-sample Mendelian randomization study.

ABSTRACT: Unsaturated fatty acids have been reported to be associated with the risk of psoriasis. However, the causal relationship between them remains unclear This study aimed to explore the causal relationship between unsaturated FAs and psoriasis. Firstly, we obtained genome-wide association study (GWAS) data for psoriasis from the FINNGEN database (number of cases = 4510, number of controls = 212,242) and different FA levels (number of samples = 114,999) from the IEU OpenGWAS Project. Secondly, the genetic correlation coefficient was calculated using linkage disequilibrium fractional regression. Thirdly, a two-sample Mendelian randomization (MR) analysis was performed using independent instrumental variables (p < 5 × 10^-8) to determine the direction of randomization. Finally, e

SUBMITTER: Lei H 

PROVIDER: S-EPMC10563715 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature